Solutions for patient financial support, prior authorization assistance, reimbursement resources, and more
NEXLIZET and NEXLETOL are the only oral nonstatins FDA approved to reduce CV risk in primary prevention and secondary prevention patients with statin intolerance.
COVERAGE
Broad access for patients prescribed NEXLIZET or NEXLETOL
>90% of all national, commercial, and Medicare payers
cover the NEXLIZET and NEXLETOL expanded indications3-5*
Medicare
approves
8 out
of 10 prescriptions
for NEXLIZET and NEXLETOL6*
In the 3rd quarter
of 2024, Medicare patients
paid on average
$43
for a 30-day supply7
*Prior authorization may apply, requiring diagnosis, statin history, and LDL-C level.
Some health plans require a prior authorization (PA) for NEXLIZET and NEXLETOL. If a PA is required, including patient information such as diagnosis, statin history, and current LDL-C level may help with approval.
Financial Support
NEXLIZET & NEXLETOL Co-Pay Savings Program
Help your eligible commercially insured patients save on their out-of-pocket costs
- $10 for each 30-day supply OR $25 for each 90-day supply of NEXLIZET or NEXLETOL
Learn more about eligibility requirements for the NEXLIZET & NEXLETOL Co-Pay card at NexCopay.com
For questions about the NEXLIZET & NEXLETOL Co-Pay Card, call 1-855-699-8814 (8:00 am-8:00 pm ET, Monday-Friday, excluding holidays)
ACCESS SUPPORT RESOURCES
Resources to support your NEXLIZET and NEXLETOL patients
NEXSTEP Navigator can help patients access NEXLIZET or NEXLETOL—contact your Esperion representative at navigator@
esperion.com to learn more.
NEXSTEP Patient Support
Resources to help your patients navigate the NEXLIZET or NEXLETOL treatment journey
Learn More
Interested in samples?
Get patients started with a 14-day sample of NEXLIZET or NEXLETOL.
Request SamplesINDICATION AND IMPORTANT SAFETY INFORMATION
Indication
NEXLIZET and NEXLETOL are indicated:
- bempedoic acid, a component of NEXLIZET and NEXLETOL, is indicated to reduce the risk of major adverse cardiovascular events (cardiovascular death, myocardial infarction, stroke, or coronary revascularization) in adults at increased risk for these events who are unable to take recommended statin therapy (including those not taking a statin).
- as an adjunct to diet and exercise:
- NEXLIZET is indicated to reduce LDL-C in adults with hypercholesterolemia, including HeFH.
- NEXLETOL is indicated, in combination with other LDL-C lowering therapies or alone when concomitant LDL-C lowering therapy is not possible, to reduce LDL-C in adults with hypercholesterolemia, including HeFH.
IMPORTANT SAFETY INFORMATION
- NEXLIZET and NEXLETOL are contraindicated in patients with a prior hypersensitivity to bempedoic acid or ezetimibe or any of the excipients. Serious hypersensitivity reactions including anaphylaxis, angioedema, rash, and urticaria have been reported.
- Hyperuricemia : Bempedoic acid, a component of NEXLIZET and NEXLETOL, may increase blood uric acid levels, which may lead to gout. Monitor as clinically indicated and initiate treatment with urate-lowering drugs as appropriate.
- Tendon Rupture : Bempedoic acid is associated with an increased risk of tendon rupture or injury. Tendon rupture occurred in 0.5% of patients treated with bempedoic acid in primary hypercholesterolemia trials, versus 0% on placebo. In the cardiovascular outcomes trial, the rates were 1.2% for bempedoic acid and 0.9% for placebo. Discontinue NEXLIZET or NEXLETOL at the first sign of tendon rupture. Consider alternative therapy in patients who have a history of tendon disorders or tendon rupture.
- The most common adverse reactions in the primary hypercholesterolemia trials of bempedoic acid in ≥2% of patients and greater than placebo were upper respiratory tract infection, muscle spasms, hyperuricemia, back pain, abdominal pain or discomfort, bronchitis, pain in extremity, anemia, and elevated liver enzymes.
- Adverse reactions reported in ≥2% of patients treated with ezetimibe (a component of NEXLIZET) and at an incidence greater than placebo in clinical trials were upper respiratory tract infection, diarrhea, arthralgia, sinusitis, pain in extremity, fatigue, and influenza.
- The most common adverse reactions (incidence ≥3% and greater than placebo) observed with NEXLIZET but not observed in clinical trials of bempedoic acid or ezetimibe, were urinary tract infection, nasopharyngitis, and constipation.
- The most common adverse reactions in the cardiovascular outcomes trial for bempedoic acid, at an incidence of ≥2% and 0.5% greater than placebo, were hyperuricemia, renal impairment, anemia, elevated liver enzymes, muscle spasms, gout, and cholelithiasis.
- Concomitant use of NEXLIZET or NEXLETOL with greater than 20 mg of simvastatin or 40 mg of pravastatin should be avoided due to the potential for increased risk of simvastatin- or pravastatin-related myopathy. Concomitant use with fibrates may increase triglycerides and decrease high-density lipoprotein cholesterol. Monitor and adjust therapies as recommended.
- Discontinue NEXLIZET or NEXLETOL when pregnancy is recognized unless the benefits of therapy outweigh the potential risks to the fetus. The benefits of breastfeeding should be considered along with the mother’s clinical need for NEXLIZET or NEXLETOL and any potential adverse effects on the breastfed infant from NEXLIZET or NEXLETOL or from the underlying maternal condition.
Report pregnancies to Esperion Therapeutics, Inc. Adverse Event reporting line at at 1-833-377-7633.
Please see full Prescribing Information for NEXLIZET and NEXLETOL.
INDICATION AND IMPORTANT SAFETY INFORMATION
Indication
NEXLIZET and NEXLETOL are indicated:
- bempedoic acid, a component of NEXLIZET and NEXLETOL, is indicated to reduce the risk of major adverse cardiovascular events (cardiovascular death, myocardial infarction, stroke, or coronary revascularization) in adults at increased risk for these events who are unable to take recommended statin therapy (including those not taking a statin).
- as an adjunct to diet and exercise:
- NEXLIZET is indicated to reduce LDL-C in adults with hypercholesterolemia, including HeFH.
- NEXLETOL is indicated, in combination with other LDL-C lowering therapies or alone when concomitant LDL-C lowering therapy is not possible, to reduce LDL-C in adults with hypercholesterolemia, including HeFH.
IMPORTANT SAFETY INFORMATION
- NEXLIZET and NEXLETOL are contraindicated in patients with a prior hypersensitivity to bempedoic acid or ezetimibe or any of the excipients. Serious hypersensitivity reactions including anaphylaxis, angioedema, rash, and urticaria have been reported.
- Hyperuricemia : Bempedoic acid, a component of NEXLIZET and NEXLETOL, may increase blood uric acid levels, which may lead to gout. Monitor as clinically indicated and initiate treatment with urate-lowering drugs as appropriate.
- Tendon Rupture : Bempedoic acid is associated with an increased risk of tendon rupture or injury. Tendon rupture occurred in 0.5% of patients treated with bempedoic acid in primary hypercholesterolemia trials, versus 0% on placebo. In the cardiovascular outcomes trial, the rates were 1.2% for bempedoic acid and 0.9% for placebo. Discontinue NEXLIZET or NEXLETOL at the first sign of tendon rupture. Consider alternative therapy in patients who have a history of tendon disorders or tendon rupture.
- The most common adverse reactions in the primary hypercholesterolemia trials of bempedoic acid in ≥2% of patients and greater than placebo were upper respiratory tract infection, muscle spasms, hyperuricemia, back pain, abdominal pain or discomfort, bronchitis, pain in extremity, anemia, and elevated liver enzymes.
- Adverse reactions reported in ≥2% of patients treated with ezetimibe (a component of NEXLIZET) and at an incidence greater than placebo in clinical trials were upper respiratory tract infection, diarrhea, arthralgia, sinusitis, pain in extremity, fatigue, and influenza.
- The most common adverse reactions (incidence ≥3% and greater than placebo) observed with NEXLIZET but not observed in clinical trials of bempedoic acid or ezetimibe, were urinary tract infection, nasopharyngitis, and constipation.
- The most common adverse reactions in the cardiovascular outcomes trial for bempedoic acid, at an incidence of ≥2% and 0.5% greater than placebo, were hyperuricemia, renal impairment, anemia, elevated liver enzymes, muscle spasms, gout, and cholelithiasis.
- Concomitant use of NEXLIZET or NEXLETOL with greater than 20 mg of simvastatin or 40 mg of pravastatin should be avoided due to the potential for increased risk of simvastatin- or pravastatin-related myopathy. Concomitant use with fibrates may increase triglycerides and decrease high-density lipoprotein cholesterol. Monitor and adjust therapies as recommended.
- Discontinue NEXLIZET or NEXLETOL when pregnancy is recognized unless the benefits of therapy outweigh the potential risks to the fetus. The benefits of breastfeeding should be considered along with the mother’s clinical need for NEXLIZET or NEXLETOL and any potential adverse effects on the breastfed infant from NEXLIZET or NEXLETOL or from the underlying maternal condition.
Report pregnancies to Esperion Therapeutics, Inc. Adverse Event reporting line at at 1-833-377-7633.
Please see full Prescribing Information for NEXLIZET and NEXLETOL.
HeFH=heterozygous familial hypercholesterolemia; LDL-C=low-density lipoprotein cholesterol; MI=myocardial infarction.
REFERENCES
1. NEXLIZET. Prescribing information. Esperion Therapeutics, Inc. 2. NEXLETOL. Prescribing information. Esperion Therapeutics, Inc. 3. Data on file. Esperion; [3]; 2024. 4. Data on file. Esperion; [Clarivate, 4Q]; 2024. 5. Data on file. Esperion; [Policy Reporter, 4Q]; 2024. 6. Data on file. Esperion; [Symphony Health, an ICON plc Company, IDV®, 04/01/2024 to 11/29/24]; 2024. 7. Data on file. Esperion; [Symphony Health, an ICON plc Company, IDV®, 07/01/2024 to 09/30/24]; 2024.