*LDL-C changes from baseline (LS mean) in 053 Trial: NEXLIZET: -36% (n=86); placebo: +2% (n=41) (P<0.001).
LDL-C changes from baseline (LS mean) for other drugs in the trial: bempedoic acid: -17% (n=88); ezetimibe: -23% (n=86).1
AR=adverse reaction; LDL-C=low-density lipoprotein cholesterol; LS=least squares.
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References: 1. NEXLIZET. Prescribing information. Esperion Therapeutics, Inc.; 09/2021. 2. Data on file. CSR 1002-053. January 2019. 3. Ray KK, Bays HE, Catapano AL, et al. Safety and efficacy of bempedoic acid to reduce LDL cholesterol. N Engl J Med. 2019;380(11):1022-1032. 4. Goldberg AC, Leiter LA, Stroes ESG, et al. Effect of bempedoic acid vs placebo added to maximally tolerated statins on low-density lipoprotein cholesterol in patients at high risk for cardiovascular disease: the CLEAR Wisdom randomized clinical trial. JAMA. 2019;322(18):1780-1788.
NEXLETOL and NEXLIZET are indicated as adjuncts to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease who require additional lowering of LDL-C.
Limitations of Use:The effect of NEXLETOL and NEXLIZET on cardiovascular morbidity and mortality has not been determined.
IMPORTANT SAFETY INFORMATION
Warnings and Precautions:
Lactation and Pregnancy:
Please see full Prescribing Information for NEXLIZET and NEXLETOL.
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